Produção Científica do CEPAM

MESTRADO ACADÊMICO EM CIÊNCIAS DA SAÚDE MEDICINA I
PRODUÇÃO CIENTÍFICA DO CEPAM

Produção científica do grupo CEPAM (artigos com a afiliação da UNILAGO). A produção total dos docentes podem ser obtidas diretamente pelo cv lattes.

2026

2025

A Systematic Review of Clinical and Experimental Periodontitis Studies Demonstrating the Expression of PPAR-Gamma: A Meta-Analysis and Bioinformatics Approach.

Hidalgo MAR, Caldeira FID, Orrico SRP, Leite FRM, Scarel-Caminaga RM.

Biomedicines. 2025, 20;13(8):2028. doi: 10.3390/biomedicines13082028.PMID:40868279

https://openurl.ebsco.com/EPDB%3Agcd%3A14%3A10663710/detailv2?sid=ebsco%3Aplink%3Acrawler-gcd&id=ebsco%3Agcd%3A187552943&crl=f&jrnl=22279059&link_origin=www.google.com

Global Salivary Proteomic Profiling of Individuals with the Co-Occurrence of Type 2 Diabetes Mellitus, Dyslipidemia, and Periodontitis.

Scarel-Caminaga RM, Caldeira FID, Corbi SCT, Bussaneli DG, Bastos AS, Orrico SRP, Salmon CR, Siqueira WL.

Int J Mol Sci. 2025 Dec 5;26(24):11778. doi: 10.3390/ijms262411778.PMID: 41465209

https://www.mdpi.com/1422-0067/26/24/11778

Ac2-26 Hydrogel Modulates IL-1β-Driven Inflammation via Mast Cell-Associated and Immune Regulatory Pathways in Diabetic Wounds

Sant'Ana M, da Silva RA, Ferreira LPS, Gil CD, Primo FL, Girol AP, Greco KV, Oliani SM.

Cells. 2025 Jun 30;14(13):999. doi: 10.3390/cells14130999.

https://www.mdpi.com/2073-4409/14/13/999

Current Trends in Clinical Trials of Prodrugs

Boreski D, Schmid VF, Bosquesi PL, et al.

Pharmaceuticals (Basel). 2025;18(2):210. Published 2025 Feb 4. doi:10.3390/ph18020210

https://www.mdpi.com/1424-8247/18/2/210

Copper, Zinc, and Selenium Levels During Pregnancy and Their Relationship with Pre-Eclampsia Risk: A Systematic Review

Goularte PdS, Imperador CHL, Piedade FH, Guerin AN, Martins KdT, Boreski D, Gabriel EA, Gabriel SA, Tiezzi DG, Chin CM

Nutrients. 2025; 17(6):1038. https://doi.org/10.3390/nu17061038

https://www.mdpi.com/2072-6643/17/6/1038

Prodrug Approach as a Strategy to Enhance Drug Permeability

de Souza MM, Gini ALR, Moura JA, Scarim CB, Chin CM, Dos Santos JL

Pharmaceuticals (Basel). 2025 Feb 21;18(3):297. doi: 10.3390/ph18030297.

https://www.mdpi.com/1424-8247/18/3/297

Efeitos da cafeína no organismo humano

Pereira Silveira, Richard; Chin, C.M

ULAKES J. Med. [S. l.], v. 5, n. 2, 2025. DOI: 10.56084/ulakesjmed.v5i2.1264.

https://www.ulakes.com.br/index.php/ulakes/article/view/1264

Ozonized Sunflower Oil: Standardization and Mechanisms of the Antimicrobial Effect

Vieira MH, Boreski D, Franzen Matte B, Arias JLO, Júnior CM, Bauab TM, Gabriel SA, Chin CM.

Int J Mol Sci. 2025 Sep 19;26(18):9156. doi: 10.3390/ijms26189156.

https://www.mdpi.com/1422-0067/26/18/9156

Machine learning can reliably predict malignancy of breast lesions based on clinical and ultrasonographic features

Buzatto IPC, Recife SA, Miguel L, Bonini RM, Onari N, Faim ALPA, Silvestre L, Carlotti DP, Fröhlich A, Tiezzi DG.

Breast Cancer Res Treat. 2025 Jun;211(3):581-593. doi: 10.1007/s10549-024-07429-0.

https://link.springer.com/article/10.1007/s10549-024-07429-0

Comparação e entre diferentes técnicas de sutura: análise da força aplicada, distribuição de tensão e potenciais complicações

HASSAN PIEDADE, Felipe; MARTINES PAULO, Helora; URZEDO FERREIRA, Tamiris; FREITAS MACEDO, Nelciely; ATIQUE GABRIEL, Sthefano.

ULAKES J. Med., [S. l.], v. 5, n. 2, 2025. DOI: 10.56084/ulakesjmed.v5i2.1298.

https://www.ulakes.com.br/index.php/ulakes/article/view/1298

Escabiose na infância: uma revisão narrativa da literatura

ROCHA, Constancia; DO CARMO SPERETTA, Emille Karoline; MACHADO SPERETTA, Weslei; LONGHIN BOSQUESI, Priscila.

ULAKES J. Med. [S. l.], v. 5, n. 2, 2025. DOI: 10.56084/ulakesjmed.v5i2.1318.

https://www.ulakes.com.br/index.php/ulakes/article/view/1318

Resposta imune gerada pela vacinação contra covid-19 em indivíduos imunocomprometidos: uma revisão narrativa de literatura

Martins de Assis, Iara; Guidotti Botaro, Fernanda; Marcelino Duarte, Ana Luiza; Rosin Prado, Flávia Cristina.

ULAKES J. Med. [S. l.], v. 4, n. 1, 2025. DOI: 10.56084/ulakesjmed.v4i1.1251

https://www.ulakes.com.br/index.php/ulakes/article/view/1251

2024

2023

The Role of Annexin A1 in DNA Damage Response in Placental Cells: Impact on Gestational Diabetes Mellitus

Moreli JB, Santos MRD, Calderon IMP, Hebeda CB, Farsky SHP, Bevilacqua E, Oliani SM

Int J Mol Sci. 2023 Jun 15;24(12):10155. doi: 10.3390/ijms241210155.

https://www.mdpi.com/1422-0067/24/12/10155

Annexin A12-26 hydrogel improves healing properties in an experimental skin lesion after induction of type 1 diabetes

Sant Ana M, Amantino CF, Silva RA, Gil CD, Greco KV, Primo FL, Girol AP, Oliani SM.

Biomed Pharmacother. 2023, 165:115230. doi: 10.1016/j.biopha.2023.115230.

https://www.sciencedirect.com/science/article/pii/S0753332223010211?via%3Dihub

Evidence Linking PPARG Genetic Variants with Periodontitis and Type 2 Diabetes Mellitus in a Brazilian Population.

Cirelli T, Nicchio IG, Bussaneli DG, Silva BR, Nepomuceno R, Orrico SRP, Cirelli JA, Theodoro LH, Barros SP, Scarel-Caminaga RM.

Int J Mol Sci. 2023 Apr 5;24(7):6760. doi: 10.3390/ijms24076760.PMID: 37047733

https://www.mdpi.com/1422-0067/24/7/6760

Vitamina D e neuropatia periférica diabética - Uma revisão integrativa.

Cardoso TF, Pereira BLB, Orrico SRP.

Brazilian Journal of Health Review 2023;6(6): 32473-32491. doi:10.34119/bjhrv6n6-456

https://ojs.brazilianjournals.com.br/ojs/index.php/BJHR/article/view/65774

Clinicopathological characteristics and recurrence risk in patients with ductal carcinoma in situ of the breast

Bruno, M H C N; Souza, V H De; Orlandini, L.F.; Carrara, H H A ; Reis, F J C; Andrade, Jm ; Bosquesi, P L; Tiezzi, D G

Mastology, Rio de Janeiro, v. 33, 2023. DOI: 10.29289/259453942023006.

https://mastology.org/journal/article/view/1643

Vitamin B12 Deficiency and Peripheral Neuropathy in patients with Type 2 Diabetes Mellitus Treated with Metformin. An integrative review.

Dias MJLE, Pererira BLB, Orrico SRP.

Brazilian Journal of Health Review 2023;6(3): 9534-9548. doi:10.34119/bjhrv6n3-091

https://ojs.brazilianjournals.com.br/ojs/index.php/BJHR/article/view/59747

Photodynamic therapy reduces cell viability, migration and triggers necroptosis in prostate tumor cells

de Melo Gomes LC, de Oliveira Cunha AB, Peixoto LFF, Zanon RG, Botelho FV, Silva MJB, Pinto-Fochi ME, Góes RM, de Paoli F, Ribeiro DL.

Photochem Photobiol Sci. 2023 Jun;22(6):1341-1356. doi: 10.1007/s43630-023-00382-9.

https://link.springer.com/article/10.1007/s43630-023-00382-9

Editorial: Epigenetic therapy against cancer: toward new molecular targets and technologies

Sousa Â, Soares CP, Chin CM, Trisciuoglio D, Valdes-Mora F

Front Cell Dev Biol. 2023 May 24;11:1218986. doi: 10.3389/fcell.2023.1218986.

https://www.frontiersin.org/journals/cell-and-developmental-biology/articles/10.3389/fcell.2023.1218986/full

Special Issue "Drug Candidates for the Treatment of Infectious Diseases"

Man Chin C, Dos Santos JL.

Pharmaceuticals (Basel). 2023 Sep 6;16(9):1257. doi: 10.3390/ph16091257.

https://www.mdpi.com/1424-8247/16/9/1257

Anatomical study of the pterygoalar bridge and the foramen crotaphitico-buccinatorius in dry skulls

Topasso Sertoro, Vinicius; Mendes Luz, Marcus Alexandre.

ULAKES J. Med. [S. l.], v. 3, n. 1, 2023. DOI: 10.56084/ulakesjmed.v3i1.825

https://www.ulakes.com.br/index.php/ulakes/article/view/825

Metodologia científica para estatística descritiva utilizando a linguagem R

FRÖHLICH, Alek; BERNARDES TURCATO, Andre; GUIMARÃES TIEZZI, Daniel.

ULAKES J. Med. [S. l.], v. 3, n. 2, 2023. DOI: 10.56084/ulakesjmed.v3i2.865

https://www.ulakes.com.br/index.php/ulakes/article/view/865

Impacto de dietas vegetarianas e veganas em crianças - uma revisão de literatura

SOARES , Laura Barbosa; QUESSADA , Isabela Moreira; OLIVEIRA , Clayton Bitecourt Vieira; PINTO-FOCHI, Maria Etelvina.

ULAKES J. Med. [S. l.], v. 3, n. 2, 2023. DOI: 10.56084/ulakesjmed.v3i2.835.

https://www.ulakes.com.br/index.php/ulakes/article/view/835

Review: Sarcopenia and Pre-Sarcopenia: Evaluation Methods in Clinical Practice

CLAPAUCH, Ruth; DE ANDRADE MOREIRA, Viviane; RIBEIRO ROCHA, Laura; JULIO LOPES, Maria Eduarda; DIAS LACOTIX, Isadora; ALVES BARON, Bárbara.

ULAKES J. Med. [S. l.], v. 3, n. 3, 2023. DOI: 10.56084/ulakesjmed.v3i3.938.

https://www.ulakes.com.br/index.php/ulakes/article/view/938

2022

ANNEXIN A1: Roles in Placenta, Cell Survival, and Nucleus.

Sousa SOd, Santos MRd, Teixeira SC, Ferro EAV, Oliani SM.

Cells. 2022; 11(13):2057. https://doi.org/10.3390/cells11132057

https://www.mdpi.com/2073-4409/11/13/2057

The role of annexin A1-derived peptide Ac2-26 on liver and kidney injuries induced by cisplatin in rats

Lucchi DBM, Sasso GRS, Sena LS, Santos DD, Franco PC, Lice I, Borges FT, Oliani SM, Gil CD.

Life Sci. 2022 Sep 1;304:120677. doi: 10.1016/j.lfs.2022.120677. Epub 2022 May 30. PMID: 35654117.

https://www.sciencedirect.com/science/article/pii/S0024320522003770?via%3Dihub

Polymorphisms in risk genes of type 2 diabetes mellitus could be also markers of susceptibility to periodontitis.

Silva ANA, Nicchio IG, da Silva BR, Martelli MGG, Hidalgo MAR, Nepomuceno R, Theodoro LH, Cirelli JA, Orrico SRP, Cirelli T, Barros SP, Scarel-Caminaga RM.

Arch Oral Biol. 2022 Nov;143:105529. doi: 10.1016/j.archoralbio.2022.105529

https://www.sciencedirect.com/science/article/pii/S0003996922001868?via%3Dihub

Insight into Recent Drug Discoveries against Trypanosomatids and Plasmodium spp Parasites: New Metal-based Compounds

Scarim CB, de Farias RL, Chiba DE, Chin CM.

Curr Med Chem. 2022;29(13):2334-2381. doi: 10.2174/0929867328666210917114912.

https://www.eurekaselect.com/article/118004

Resveratrol and Curcumin for Chagas Disease Treatment. A Systematic Review

Imperador CHL, Scarim CB, Bosquesi PL, et al.

Pharmaceuticals (Basel). 2022;15(5):609. Published 2022 May 15. doi:10.3390/ph15050609

https://www.mdpi.com/1424-8247/15/5/609

Drug/Lead Compound Hydroxymethylation as a Simple Approach to Enhance Pharmacodynamic and Pharmacokinetic Properties

Santos SS, Gonzaga RV, Scarim CB, Chin CM, et al.

Front Chem. 2022;9:734983. Published 2022 Feb 14. doi:10.3389/fchem.2021.734983

https://www.frontiersin.org/journals/chemistry/articles/10.3389/fchem.2021.734983/full

Recent Trends in Drug Development for the Treatment of Adenocarcinoma Breast Cancer: Thiazole, Triazole, and Thiosemicarbazone Analogues as Efficient Scaffolds

Scarim CB, Chin CM

Anticancer Agents Med Chem. 2022;22(12):2204-2240. doi:10.2174/187152062166621120115281

https://www.eurekaselect.com/article/119181

Perspectives and challenges to discovering hemoglobin-inducing agents in Sickle Cell Disease

Pavan AR, Lopes JR, Lima Imperador CH, Man Chin C and dos Santos JL (2022)

Front. Med. 9:1002063. doi: 10.3389/fmed.2022.1002063

https://www.frontiersin.org/journals/medicine/articles/10.3389/fmed.2022.1002063/full

COVID-19: The question of genetic diversity and therapeutic intervention approaches

Figueiredo DLA, Ximenez JPB, Seiva FRF, Panis C, Bezerra RDS, Ferrasa A, Chin CM et al.

Genet Mol Biol. 2022 Apr 8;44(1 Suppl 1):e20200452. doi: 10.1590/1678-4685-GMB-2020-0452.

https://www.scielo.br/j/gmb/a/gdghSWNFyG9qnh9rNGDZyGn/?lang=en

10-year opportunistic mammographic screening scenario in Brazil and its impact on breast cancer early detection: a nationwide population-based study

Cuoghi IC, da Silva Soares MF, Dos Santos GMC, Dos-Reis FJC, Poli-Neto OB, de Andrade JM, Bosquesi PL, Orlandini LF, Tiezzi DG.

J Glob Health. 2022 Oct 14;12:04061. doi: 10.7189/jogh.12.04061

https://jogh.org/2022/jogh-12-04061

High-lipid nutritional environment in different ontogenetic periods induce developmental programming of rat prostate at aging

Pereira Scarpelli T, Pytlowanciv EZ, Pinto-Fochi ME, Taboga SR, Góes RM. Reproduction. 2022 Dec 2;165(1):65-78. doi: 10.1530/REP-22-0258. PMID: 36194431.

https://academic.oup.com/reproduction/article-abstract/165/1/65/8217216?redirectedFrom=fulltext&login=false

Reminiscências das lições de anthropotomia

LUZ MA M

ULAKES J. Med. [S. l.], v. 2, n. 1, 2022. DOI: 10.56084/ulakesjmed.v2i1.654

https://www.ulakes.com.br/index.php/ulakes/article/view/654

Determinação da permeação transcutânea do pró-fármaco hidroximetilnitrofural (NFOH)

Brito Fukushima, Mayna; Galdorfini Chiari, Bruna; Bosquesi, PL; Chin, M C; Borges Isaac, Vera Lucia.

ULAKES J. Med. [S. l.], v. 2, n. 1, 2022. DOI: 10.56084/ulakesjmed.v2i1.656

https://www.ulakes.com.br/index.php/ulakes/article/view/656

Doença aterosclerótica multiarterial e aneurismas múltiplos: estudo anatomopatológico macroscópico e microscópico em cadáver do sexo masculino

MANO , Gabriela Braga Cabrera; MANO , Rafaela Braga Cabrera; RODRIGUES, Rafaela Prudêncio; MENEGUETTE , Cícero; MENDES LUZ, Marcus Alexandre.

ULAKES J. Med. [S. l.], v. 2, n. 1, 2022. DOI: 10.56084/ulakesjmed.v2i1.653

https://www.ulakes.com.br/index.php/ulakes/article/view/653

Neuronutrição: um estudo de revisão sobre o uso de nutrientes, isolados e combinados, no controle dos sintomas de estresse e/ou ansiedade

RODRIGUES MACARI , Laura; PALMA , Larissa; GARCIA BUNEMER GUERRA, Bianca; PEREIRA VATANABE, Izabela.

ULAKES J. Med., [S. l.], v. 2, n. 2, 2022.

https://www.ulakes.com.br/index.php/ulakes/article/view/730

Sinal de Golf Ball presente em feto de 28 semanas: um relato de caso

ATIQUE GABRIEL, Edmo; MELCHIORI FRANCO, Ana Carolina; MENDES JÚNIOR, Carlos Henrique; PELLICANO MESABARBA, Nykolas.

ULAKES J. Med. [S. l.], v. 2, n. 2, 2022.

https://www.ulakes.com.br/index.php/ulakes/article/view/659

Impacto nutricional na Doença de Alzheimer: um estudo de revisão sobre o uso de nutrientes e compostos nutricionais na condição

Beraldo , Beatriz; Carolina Passoni De Souza, Maria; Siqueira Cattelan, Rafaela; Pereira Vatanabe, Izabela.

ULAKES J. Med. [S. l.], v. 2, n. 3, 2022. DOI: 10.56084/ulakesjmed.v2i3.729.

https://www.ulakes.com.br/index.php/ulakes/article/view/729

Efeitos cognitivos da ansiedade em idosos: um estudo de revisão

Coimbra Sternieri, Caio; Petramali Stábile , Leonardo; Flora Martins Saes, Anna; Pereira Vatanabe, Izabela.

ULAKES J. Med. [S. l.], v. 2, n. 3, 2022. DOI: 10.56084/ulakesjmed.v2i3.737.

https://www.ulakes.com.br/index.php/ulakes/article/view/737

O uso da ultrassonografia dermatológica de pele e subcutâneo para auxílio no manejo dos eventos adversos dos procedimentos injetáveis

Sequin Lopes, Rhuan; Veanholi, Marcos Vinícius; Baruffi De Castro, Vinicius; Bueno Ribeiro Garcia, Eliane Regina; Atique Gabriel, Sthefano.

ULAKES J. Med. [S. l.], v. 2, n. 3, 2022. DOI: 10.56084/ulakesjmed.v2i3.716.

https://www.ulakes.com.br/index.php/ulakes/article/view/716

Depressão pós-parto: revisão da literatura

Aquino, Laise Cordeiro De; Cordeiro, Lozanio Silveira; Barbosa , Paullie Cordeiro De Oliveira; Martin, Natália; Pinto-Fochi, Maria Etelvina.

ULAKES J. Med. [S. l.], v. 2, n. 3, 2022. DOI: 10.56084/ulakesjmed.v2i3.718

https://www.ulakes.com.br/index.php/ulakes/article/view/718

2021

2020

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